Capsaicin, the compound responsible for the burning sensation in chili peppers, has been researched for its potential therapeutic benefits, including reducing cholesterol and blood sugar levels, and exhibiting anti-inflammatory and analgesic properties. Hamilton's PRP-C18 reversed-phase HPLC column was used to isolate major capsaicinoids, with formic acid as the aqueous mobile phase, achieving good correlation with literature values at 10190 Scoville Heat Units. The Hamilton PRP-C18 column demonstrated excellent peak shape and can be easily regenerated, making it an indispensable tool for synthetic chemists.
Liquid chromatography–ion mobility spectrometry–high-resolution mass spectrometry (LC–IMS–HRMS) shows elephant seal pups carry more PFAS than their mothers do.
This week's Chromatography Online highlights include olive waste antioxidant recovery, food and tea analysis, EV isolation, mRNA vaccine purification, perfusion chromatography for oligonucleotides, mass spectrometry in teaching and career advice from “Women in Chromatography.”
Kinjal Bhatt and Ina Varfaj call AI a chromatography equalizer only if training and access keep pace, framing the risk as implementation, not technology.
Gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS) reveal lasting brain cholesterol loss after myelin damage.
Kinjal Bhatt would expose early-career scientists to the field sooner, while Ina Varfaj says a broken chromatography column taught her failure is normal.