Tips & Tricks: GPC/SEC Is This Real? Unexpected Peak Shapes

December 6, 2011

The Column

The Column, The Column-12-06-2011, Volume 7, Issue 22

GPC/SEC samples often show broad and/or multimodal peaks that are not baseline separated and look strange to users of other chromatographic techniques. However, although many weird looking peaks are possible in macromolecular characterization, some peaks are stranger than others and it is worth checking if the observed signal truly describes the sample.

GPC/SEC samples often show broad and/or multimodal peaks that are not baseline separated and look strange to users of other chromatographic techniques. However, although many weird looking peaks are possible in macromolecular characterization, some peaks are stranger than others and it is worth checking if the observed signal truly describes the sample. Therefore, it is good to know some tricks and hints that help identify measuring artefacts.

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