Vol 32 No 9 LCGC North America September 2014 Regular Issue PDF

Piotr Alvarez explains how HILIC complements reversed-phase LC for GLP-1 peptides, and why the field is moving toward MS-friendly TFA alternatives.

In this third part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses the retention mechanism of hydrophobic interaction.

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) shows hydrogel cuts dogs' peak bupivacaine blood levels fivefold.

In the second part of our interview, Novartis's Martina Lioi talks about using IP-HILIC and RP for lipid-siRNA impurities

LCGC International spoke to David Hage, Sanduni Heenkenda, and Zoe Zingler of the University of Nebraska-Lincoln about how green chemistry principles are reshaping affinity chromatography.

Panelists identify the parameters that make or break peptide method robustness and tech transfer, including temperature, flow rate, and dwell volume.

In Part 2 of "Conversations with Michael Dong," the LCGC column editor discusses HPLC columns for pharmaceutical analysis and the case for short columns.

Gas chromatography-mass spectrometry (GC–MS) shows scarlet macaw feather scent varies by sex and mate status.