Adrian Clarke

Analytical quality by design (AQbD) lifecycle series tackles risk-based methods

LCGC presents the first in a series of articles exploring the current analytical procedure lifecycle practices with multiple industrial and regulatory experts and consultants in the field, and addresses if this is a great opportunity to develop a greater understanding of method performance to ensure continuous improvement and regulatory flexibility, or if it is just additional challenges, complexity, and headaches.

The Chromatographic Society (ChromSoc) Spring Symposium, The Chromatographic (Analytical) Method Life Cycle (2026): From Cradle to Grave (III), co-organised with the Joint Pharmaceutical Analysis Group (JPAG), will be held at Burlington House (London) from 18–19th May 2026.

To reach satisfactory results in terms of accurate retention time prediction, new in silico optimization approaches must be considered.

This article will discuss the benefits of 2D-LC and multiple application areas in (bio)pharmaceutical analysis, and will highlight the challenges and future outlook.

An introduction from the guest editors of this special supplement from LCGC Europe focusing on recent trends in pharmaceutical analysis.

This study demonstrates a new LEAN approach and method, where 25 solvents can be simultaneously determined based on predetermined relative response factors (RRFs) against an internal standard (decane) with only one injection of sample solution.