Practical 2D-LC in Drug Metabolism Studies and Bioanalysis
February 1st 2022Filip Cuyckens from Janssen R&D in Belgium spoke to LCGC Europe about recent innovative approaches he and his team developed to support drug metabolism and pharmacokinetic studies, and the inventive role that two-dimensional liquid chromatography (2D-LC) plays in his laboratory to boost sensitivity, solve recovery issues, and increase overall efficiency.
Fast GC–MS for Analyzing Antioxidants and Industrial Food Analysis Applications
July 12th 2021LCGC Europe spoke to Hans-Gerd Janssen from the Unilever Foods Innovation Centre in The Netherlands, about the advantages of a novel, rapid method to analyze antioxidants that inhibit oxidation, and he explains that the maturity of GC technology is actually an advantage to the analyst.
Rising Stars of Separation Science: Katelynn Perrault
July 8th 2021This month we interview Katelynn Perrault, Associate Professor of Forensic Sciences and Chemistry at Chaminade University of Honolulu in Honolulu, Hawaii, about her work translating 1D GC methods to effective comprehensive 2D GC (GC×GC) methods for forensic applications and the benefits that GC×GC offers the analyst.
Non-Targeted Analysis of PFAS in Surface Water Using Fragment Ion Flagging
June 1st 2021Per- and polyfluoroalkyl substances (PFAS) in surface water have become a major concern due to their persistency and toxicity. We recently spoke to Stefan Van Leeuwen and Bjorn Berendsen of Wageningen Food Safety Research (WFSR), in The Netherlands, about their novel research into non-targeted PFAS screening using an LC–HRMS method with fragment ion flagging.
Investigating Arson Attacks Using Multidimensional Gas Chromatography (GC×GC)
September 7th 2020A novel chemical fingerprinting method has been developed using multidimensional chromatography and multivariate analysis to investigate potential arson attacks. The Column spoke to Oliver Jones and Jessica Pandohee of RMIT University in Melbourne, Australia, about their research in this field.
Industrious Innovations in Polymer Analysis
July 31st 2020LCGC Europe spoke to Ton Brooijmans, from DSM Coating Resins in The Netherlands, about the array of innovative techniques he has recently implemented in his laboratory to analyse polymers. These include the development of a selective derivatization technique followed by size‑exclusion chromatography (SEC) to analyze polymeric carboxylic acid functionality, the benefits of non-aqueous ion‑exchange chromatography (NAIEC) for analysing synthetic macromolecules, and the important role of pyrolysis gas chromatography (Py‑GC–MS) in polymer analysis. Brooijmans also discusses future trends in this application area.
Practical Two-Dimensional Liquid Chromatography in Drug Metabolism Studies and Bioanalysis
June 30th 2020Filip Cuyckens from Janssen R&D in Belgium spoke to LCGC Europe about recent innovative approaches he and his team developed to support drug metabolism and pharmacokinetic studies, and the inventive role that two-dimensional liquid chromatography (2D-LC) plays in his laboratory to boost sensitivity, solve recovery issues, and increase overall efficiency.
Exploring Energetic Materials Using Nontargeted Analysis
December 1st 2019LCGC Europe spoke to Leon Barron and Matteo Gallidabino to discuss novel nontargeted approaches to analyze explosive materials using ion chromatography (IC) with high resolution mass spectrometry (HRMS), and the challenges and solutions analysts can encounter when developing nontargeted methods.
Sizing Up Size-Exclusion Chromatography (Part 2)
November 1st 2019In the second part of this interview on size-exclusion chromatography (SEC) André Striegel discusses the benefits of the technique to analyze nanoparticles and quantum dots, the complementary role of hydrodynamic chromatography (HDC), and the future of SEC in two-dimensional liquid chromatography (2D-LC) separations.
Petroleum Pollution Analysis with Ramped Pyrolysis GC–MS
October 1st 2019LCGC Europe spoke to Zhanfei Liu from the Marine Science Institute at the University of Texas at Austin, Texas USA, about the advantages of ramped pyrolysis GC–MS to analyze petroleum pollution from the Deepwater Horizon oil spill.
Sizing Up Size-Exclusion Chromatography
August 1st 2019André Striegel spoke to LCGC Europe about innovations in size-exclusion chromatography (SEC) in polymer analysis, including the benefits of hyphenating SEC with on-line multi-angle static light scattering (MALS) and differential refractometry (DRI) detection, the non-trivial nature of a “trivial” solution, the complementary value of “interaction” polymer liquid chromatography (LC) techniques, and the role of quintuple detection in practice.
The Benefits of Data-Independent Acquisition in Metabolomics
March 1st 2019Data-independent acquisition (DIA) makes it possible to re-interrogate data from earlier analyses to determine if new compounds have appeared in a sample previously analyzed. In this interview, Craig Wheelock of the Karolinska Institute discusses the use of DIA in metabolomics.
Going Green in Pharmaceutical Analysis
February 1st 2019LCGC Europe spoke to Yong Liu and Adam Socia from MSD about the cost-saving benefits of implementing green chromatography in the pharmaceutical sector, the importance of analytical method volume intensity (AMVI), and effective practices to reduce solvent consumption and replace harmful solvents, including supercritical fluid chromatography (SFC), fast chromatography, and “cocktail chromatography”.
Going Green in Pharmaceutical Analysis
February 1st 2019LCGC Asia Pacific spoke to Yong Liu and Adam Socia from MSD about the cost-saving benefits of implementing green chromatography in the pharmaceutical sector, the importance of analytical method volume intensity (AMVI), and effective practices to reduce solvent consumption and replace harmful solvents, including supercritical fluid chromatography (SFC), fast chromatography, and “cocktail chromatography”.
Moving Gas Chromatography Forward
December 1st 2018Is gas chromatography a mature technology? LCGC Europe spoke to Ronda Gras about a range of GC projects she has been working on to extend the scope of the technique, including a multi-hyphenated approach combining three modes of detection, a miniaturized micromachined GC system, and a novel in situ method to detect carbon dioxide in various matrices by incorporating 3D-printing technology in a FID.