Amitha K. Hewavitharana

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The Importance of Complete Overlapping of Analyte and Internal Standard Peaks in Eliminating Matrix Effects with Liquid Chromatography–Mass Spectrometry (LC–MS)

The Importance of Complete Overlapping of Analyte and Internal Standard Peaks in Eliminating Matrix Effects with Liquid Chromatography–Mass Spectrometry (LC–MS)

Amitha K. Hewavitharana;P. Nicholas Shaw;H.D.C. Smyth;L.P. Samaranayake;H.M.H.N. Bandara
July 1st 2021

Ensuring complete overlapping (coelution) of analyte and internal standard peaks can be critical for eliminating matrix effects in LC–MS/MS analysis.

LCGC6_i6-833090-1416906622553.jpg

Strategies for the Detection and Elimination of Matrix Effects in Quantitative LC–MS Analysis

Swee K. Tan;P. Nicholas Shaw;Amitha K. Hewavitharana
January 14th 2014

We assessed a simple method based on recovery for the detection of matrix effects and two alternative methods for the rectification of matrix effects in LC–MS: standard addition and the coeluting internal standard method.

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