Koen Vanhoutte

Koen Vanhoutte of Johnson & Johnson Innovative Medicine concludes his four-part interview with his opinions on what the shift from routine testing to model‑based analytical science means in in practical terms for today’s analytical laboratories.

In‑silico tools like retention‑time prediction are gaining attention. Koen Vanhoutte of Johnson & Johnson Innovative Medicine discusses how chromatographers should use these tools effectively without losing confidence in experimental data.

As NIR and chemometric models rely heavily on chromatographic reference data, Koen Vanhoutte discusses the implications for the future role and expectations of chromatography in analytical science.

In the first of a four-part interview conducted at analytica 2026, Koen Vanhoutte of Johnson & Johnson Innovative Medicine discusses how self‑optimizing LC workflows are changing the way chromatographic methods are developed compared with traditional trial‑and‑error approaches.

Potentiometry is a new detection method for liquid chromatography (LC) and capillary electrophoresis (CE). The principle behind this method is familiar to chromatographers because the signals depend on the partitioning tendency of analytes over the sensor coating and the eluent. This partitioning provokes a change in the surface potential and the detection of these changes can be classified as "potentiometric". A conversion algorithm is needed to convert the generated signals to concentration-related tracings (chromatograms).