Nico Vervoort

Potentiometry is a new detection method for liquid chromatography (LC) and capillary electrophoresis (CE). The principle behind this method is familiar to chromatographers because the signals depend on the partitioning tendency of analytes over the sensor coating and the eluent. This partitioning provokes a change in the surface potential and the detection of these changes can be classified as "potentiometric". A conversion algorithm is needed to convert the generated signals to concentration-related tracings (chromatograms).

The authors discuss the application of shear-driven chromatography, a technique that depends on viscous drag to propel mobile phase in high-resolution/high-speed liquid chromatography. This method, it is claimed, overcomes the pressure- and voltage-drop limitations of both HPLC and CEC. Early development of the technique is reviewed and updated with the current status of the group's work. Also covered are the challenges faced and opportunities available to interface such systems to MS and UV/vis absorption detectors.