Recent Advances in Silica-Based Monolithic HPLC Columns
In this article, silica-based monolithic columns are compared and contrasted to packed microparticulate columns. Some of the challenges developing commercial silica rods and encapsulated monolith columns are described, including the development of a 2-mm i.d. column. A study of wall effects in these monolith columns was performed. Future trends and challenges in improving the performance of silica-based monolith columns are described.