Maria Eugênia C. Queiroz

Reducing matrix effects during LC–MS/MS bioanalysis is paramount. Improving sample preparation techniques is the best way to combat this issue.

This month's guest authors review the application of solid-phase microextraction (SPME) to the analysis of drugs in human plasma discussing important factors in the optimization of extraction efficiency. The column concludes with a discussion of method validation issues.

This month'ss guest authors review the application of solid-phase SPME to the analysis of drugs in human plasma.