Shear-Driven Flow LC: Dispensing with Pumps and Voltage Supplied for Increased Speed and Resolution

The authors discuss the application of shear-driven chromatography, a technique that depends on viscous drag to propel mobile phase in high-resolution/high-speed liquid chromatography. This method, it is claimed, overcomes the pressure- and voltage-drop limitations of both HPLC and CEC. Early development of the technique is reviewed and updated with the current status of the group's work. Also covered are the challenges faced and opportunities available to interface such systems to MS and UV/vis absorption detectors.