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© 2022 MJH Life Sciences™ and Chromatography Online. All rights reserved.
IMS is a valuable tool for biopharmaceutical analysis. Two formats in particular have proven useful: cyclic IMS and structures for lossless manipulations (SLIM).
Hydrogen–deuterium exchange–mass spectrometry enables determination of higher order structures of biopharmaceuticals and direct comparisons between a biosimilar and its proprietary analog.
The guest authors present a strategy for validating a capillary isoelectric focusing method intended to quantitate impurities in a protein drug substance.