Shodex, Showa Denko America, Inc.

With the increase of research with Eudragit, consistent molecular weight measurements have become more prevalent. Shodex has shown a repeatable SEC method using the GF-510 HQ column.

Due to the highly polar nature of saccharides, the analysis of sugars is typically achieved using hydrophilic interaction chromatography (HILIC).

Shodex introduces the VG-50 4E column packed with a durable polymer based packing material modified with chemically stable tertiary amino functional groups. Shodex VG-50 4E is suitable for saccharide analysis and provides a fast reliable method for the determination of lactose and lactulose.

Lactulose, a semi-synthetic disaccharide, is a useful indicator for heat induced modifications in milk. Lactulose can be derived from lactose by alkaline isomerization or enzymatic transgalactosylation of fructose.

Shodex/Showa Denko America Inc.

Sample pretreatment is often a time consuming and labor-intensive step which can be a restricting factor for the rapid analysis. This is especially true for the analysis of drugs in biofluids containing many interfering matrices.

Excipients are pharmacologically inactive substances used as carrier and release controllers for active drug ingredients. A significant amount (30–80% solid) of polymeric excipients such as hydroxyl propyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), hydroxypropyl methyl cellulose acetate succinate (HPMCAS), and povidone are used.

Hydrophilic interaction chromatography (HILIC) has become a popularly used separation mode for carbohydrate HPLC method. There are wide variations in HILIC stationary phase.