Kanna Ito | Authors

Shodex/Showa Denko America Inc.

Sample pretreatment is often a time consuming and labor-intensive step which can be a restricting factor for the rapid analysis. This is especially true for the analysis of drugs in biofluids containing many interfering matrices.

Excipients are pharmacologically inactive substances used as carrier and release controllers for active drug ingredients. A significant amount (30–80% solid) of polymeric excipients such as hydroxyl propyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), hydroxypropyl methyl cellulose acetate succinate (HPMCAS), and povidone are used.

Hydrophilic interaction chromatography (HILIC) has become a popularly used separation mode for carbohydrate HPLC method. There are wide variations in HILIC stationary phase.