Stephane Moreau | Authors


Automating Analysis of Antibiotics in Blood

Therapeutic drug monitoring (TDM) is an important method for determining both dose and optimal effective level of a drug in the blood, preventing side effects such as kidney damage. Using the antibiotic classes aminoglycoside and vancomycin as examples, an analysis method is presented that combines fully automated sample preparation with ultrahigh-pressure liquid chromatography–triple quadrupole-mass spectrometry (UHPLC–TQMS).

Direct Liquid Chromatography Tandem Mass Spectrometry Analysis of Glyphosate, AMPA, Glufosinate, and MPPA in Water Without Derivatization

This article describes a direct analysis of glyphosate, aminomethylphosphonic acid (AMPA), glufosinate, and 3-methylphosphinicopropionic acid (MPPA) in water by liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) without derivatization. The chromatographic separation was performed using a hydrophilic interaction liquid chromatography (HILIC) column and typical LC–MS mobile phases. Method performance was evaluated, showing excellent results. The low limits of quantification (LLOQs) obtained meet the requirements of EU guidelines and could also be used to get an agreement in France where regulations require lower LLOQs (NOR: DEVL1703763V).