Pauline Griffeuille is with the Pharmacology and Toxicology Department at Limoges University Hospital.
The main objectives of this study were to develop a method for the measurement of cocaine derivatives in oral fluid by coupling a probe electrospray ionization (PESI) source with quadrupole time-of-flight (QTOF). The three cocaine derivatives considered were: benzoylecgonine (BZE), cocaine, and ecgonine-methylester (EME).
In this study, a probe electrospray ionization coupled to mass spectrometry (PESI-MS) method for ultra-rapid determination of MtF in plasma by isotope dilution was developed.
The benefits of a PESI-MS/MS approach to detect illicit drugs in saliva.
