Pauline Griffeuille

Pauline Griffeuille is with the Pharmacology and Toxicology Department at Limoges University Hospital.

Articles by Pauline Griffeuille

Capture the essence of drug addiction International Day against Drug Abuse and Illicit Drug Trafficking visuals featuring drugs set against a dark backdrop | Image Credit: © AkuAku - stock.adobe.com.

SFC–HRMS: Application to the Detection of Drugs of Abuse in Oral Fluid

ByElisa Jousselin,Sylvain Dulaurent,Pauline Griffeuille,Souleiman El Balkhi,Franck Saint-Marcoux

September 28th 2026

A novel SFC–QTOF-MS method accurately detected 10 drugs in oral fluid, matching LC–MS/MS in 83 DUID cases while reducing run time by 42% and organic solvent use by 81%.

Method Validation for the Determination of Cocaine Derivatives in Oral Fluid Using PESI and LC–MS

ByElisa Jousselin,Elies Zarrouk,Pauline Griffeuille,Sylvain Dulaurent,Souleiman El Balkhi,Franck Saint-Marcoux

September 19th 2025

The main objectives of this study were to develop a method for the measurement of cocaine derivatives in oral fluid by coupling a probe electrospray ionization (PESI) source with quadrupole time-of-flight (QTOF). The three cocaine derivatives considered were: benzoylecgonine (BZE), cocaine, and ecgonine-methylester (EME).

Probe Electrospray Ionization-Mass Spectrometry and Isotope Dilution Approaches for Ultrafast Measurement of Metformin

ByPauline Griffeuille,Sylvain Dulaurent,Franck Saint-Marcoux

February 1st 2023

In this study, a probe electrospray ionization coupled to mass spectrometry (PESI-MS) method for ultra-rapid determination of MtF in plasma by isotope dilution was developed.