The Application Notebook-09-01-2014

The Application Notebook
Pharmaceutical/Drug Discovery

September 01, 2014

Paper spray mass spectrometry (MS) allows for the direct analysis of pharmaceuticals, drugs of abuse, and other small molecules from blood, urine, and other biofluids (1,2).

In recent years, the increasing cost and uncertain availability of helium have prompted many labs to explore the use of hydrogen as an alternate carrier gas.

The Application Notebook

Carbendazim is a widely used, broad-spectrum fungicide to control mold on citrus crops.

The Application Notebook

Polypeptide hormones play key endocrine functions in humans. In particular, angiotensins are oligopeptide hormones, critical in the regulation of body fluids which ultimately affect blood pressure levels in individuals.

The Application Notebook

The use of mass spectrometry as a means of detection is becoming increasingly more common among research laboratories in the field of proteomics.

The Application Notebook
Food and Beverage

September 01, 2014

Due to the highly polar nature of saccharides, the analysis of sugars is typically achieved using hydrophilic interaction chromatography (HILIC).

The Application Notebook
Food and Beverage

September 01, 2014

Organic arsenic compounds added to feed stocks of chicken and poultry pose serious environmental and ecological threats.

The Application Notebook

USP assay methods are widely used for quality control and stability testing.

Organophosphate pesticides (OPPs) are widely used globally for agricultural pest control.

The Application Notebook
Pharmaceutical/Drug Discovery

September 01, 2014

The European Pharmacopoeia (Ph. Eur.) defines requirements for the qualitative and quantitative composition of medicines, as well as the tests to be carried out on medicines and on substances and materials used in their production.

The Application Notebook

Oligonucleotides are in the center of many recent research projects including genetic testing, polymerase chain reactions (PCR), forensics, and DNA/RNA silencing.

The Application Notebook

Anthrolysin (ALO) is a pore forming cholesterol-dependent cytolysin (CDC) secreted by Bacillus antracis.

The Application Notebook

Proteins of the Bcl-2 family are molecular transducers sensitive to internal and external apoptotic signals that play a key role in the regulation of apoptosis.

The Application Notebook

Carbon-clad zirconia phases offer dramatically different chromatographic selectivity for structurally similar compounds when compared to traditional silica-based bonded phases.

Deoxynivalenol is a common mycotoxin found in agricultural grain crops and final consumer processed products.

The Application Notebook

This study illustrates the successful combination of fast GC and tandem mass spectrometry to determine 360 pesticides spiked in a QuEChERS apple extract.

Pharmaceutical and personal care products (PPCPs) are products used for personal health or cosmetic reasons.

The numerous advantages of translating gradient chromatographic methods between the differing formats of liquid chromatography (LC) have been explored and discussed.

The Application Notebook
Pharmaceutical/Drug Discovery

September 01, 2014

Statistic copolymers of methyl methacrylate (MMA) and methacrylic acid (MAA) are widely used in pharmaceutical applications.

The Application Notebook

The Agilent 1200 Infinity Series HDR-DAD Impurity Analyzer System covers a wide linear range typically up to 6000 mAU and enables the analysis of impurities typically down to 0.2 mAU.

Methadone is a commonly prescribed pain management type drug. As such, patients are monitored on a routine basis.

The Application Notebook

Monoclonal antibodies (mAbs) form a major class of biologics and recently biosimilars and biobetters are being added to the growing inventory of therapeutics.

The Application Notebook

Optimizing separation of ionizable compounds in order to find robust conditions has become an important part of method development in liquid chromatography.

The Application Notebook
Polymer

September 01, 2014

Synthetic elastomers have replaced natural rubber to an astonishing degree, and account for more than 70% of the rubber used today.

Two species of spearmint oil (Mentha spicata and Mentha gracilis) are cultivated in the United States.

Starch is used for a variety of industrial and nutritional purposes. Its functional properties are influenced by the ratio and molar masses of its macromolecular constituents, which vary with source, crop year, and climate.

The Application Notebook

Since the gas flow required for the separation step in gas chromatography is frequently lower than that required to optimize the detection, nitrogen is used as a make-up gas to increase the gas flow for detection.

The Application Notebook
Pharmaceutical/Drug Discovery

September 01, 2014

The unique surface chemistry of the FLARE diamond core-shell column combines ionic and hydrophobic separation mechanisms to effectively retain a variety of chemical species in a single run.

Issue PDF
The Application Notebook

September 01, 2014

Click the title above to open the LCGC North America September 2014 Application Notebook, Vol 32 No s9, in an interactive PDF format.