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The Column-01-15-2013

The Column

"Critical to Quality" Measurements of Protein Aggregation in Biopharmaceuticals

January 15, 2013

Articles

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In biopharmaceutical development the stability of biological molecules in drug formulations is important. This article describes three different approaches to the measurement and quantification of aggregates in protein solutions, and highlights the range of information that each technique can provide about the sample.

Bugs boost wine aroma

January 15, 2013

News

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A new strain of the enzyme ß-glucosidase isolated from the microbial strain Aureobasidium pullulans (Sp? ß-gl) improves the aroma of wine, according to a team of Brazilian researchers.1

Characterization of Antibody-Drug Conjugates by SEC with Combined Light Scattering, dRI and UV Detection

January 15, 2013

Articles

9

1

There has been a significant resurgence in the development of antibody-drug conjugates (ADC) as target-specific therapeutic agents for cancer treatments. This article presents a method for DAR determination based on size-exclusion chromatography with multi-angle light scattering (SEC?MALS) combined with ultraviolet (UV) absorption and differential refractive index (dRI) detection.

EDCs alter US water quality

January 15, 2013

News

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Previously unreported biological activity of endocrine disrupting chemicals (EDCs) has been detected in water samples from 14 states in the US by researchers at the National Cancer Institute, Maryland, USA.1