There has been a significant resurgence in the development of antibody-drug conjugates (ADC) as target-specific therapeutic agents for cancer treatments. This article presents a method for DAR determination based on size-exclusion chromatography with multi-angle light scattering (SEC?MALS) combined with ultraviolet (UV) absorption and differential refractive index (dRI) detection.
There has been a significant resurgence in the development of antibody‑drug conjugates (ADC) as target-specific therapeutic agents for cancer treatments. A critical factor for ADC formulations is the drug‑to‑antibody ratio (DAR), which describes the degree of modification. This article presents a method for DAR determination based on size-exclusion chromatography with multi-angle light scattering (SEC–MALS) combined with ultraviolet (UV) absorption and differential refractive index (dRI) detection.
Targeted Blood Lipidomics of Colorectal Cancer: An HTC-18 Interview with Jef Focant
July 26th 2024At HTC-18 in Leuven, Executive Editor of LCGC International, Alasdair Matheson, spoke to Jef Focant from the University of Liege about his talk entitled, “Targeted Blood Lipidomics of Colorectal Cancer."
Carol Robinson Awarded 2024 Lifetime Achievement European Inventor Award
July 24th 2024Carol Robinson of the University of Oxford has received the European Inventor Award 2024 for Lifetime Achievement from the European Patent Office for her work bringing mass spectrometry to structural biology.