"Lean" Approaches to Reduce Waste when Performing Chromatography Analysis
"Lean" approaches are used to reduce wastes and costs when performing chromatographic procedures. The terminology of this approach is introduced in this article, together with illustrative examples and suggestions.
"Lean" approaches are used to reduce wastes and costs when performing chromatographic procedures. The terminology of this approach is introduced in this article, together with illustrative examples and suggestions. Although this “Lean” methodology was originally developed for industrial use or factory environments, it is increasingly being used in analytical laboratories — most notably in pharmaceutical companies. A follow-up article in the next issue of The Column will describe how to achieve reductions in variations (“Sigma”) that can occur in chromatographic operations.
RAFA 2024: Giorgia Purcaro on Multidimensional GC for Mineral Oil Hydrocarbon Analysis
November 27th 2024Giorgia Purcaro from the University of Liège was interviewed at RAFA 2024 by LCGC International on the benefits of modern multidimensional GC methods to analyze mineral oil aromatic hydrocarbons (MOAH) and mineral oil saturated hydrocarbons (MOSH).
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
Identifying Antioxidative Properties in Berries with UHPLC-MS
Published: November 27th 2024 | Updated: November 27th 2024A recent study identified and quantified anthocyanin (which are known for their antioxidative properties and potential effectiveness against depression) in blueberries, blackberries, black mulberries, and cranberries using ultra high-pressure liquid chromatography (UHPLC) followed by in vivo evaluation of their antidepressant-like activities.
In Conversation with the EAS Award Winner for Outstanding Achievements in Mass Spectrometry
November 27th 2024As part of our EAS 2024 coverage, we recently interviewed Benjamin Garcia of the Washington University in St. Louis about his work and his being awarded the EAS Award for Outstanding Achievements in Mass Spectrometry.
