Automated column and mobile phase screening is the current trend in the pharmaceutical industry to develop chiral methods. This study presents comprehensive strategies for automated rapid chiral HPLC method development including normal-phase, reversed-phase and polar organic phase separation modes.
LC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?
A team of scientists have developed a new analytical method to evaluate the quality of new renewable transportation fuels and intermediate organic liquid products (OLPs), as the current method has been developed for petroleum-based feedstocks and so is not suitable.