Ultra-High Resolution Chromatography Using 500 mm UHPLC Columns for Detection Of Hidden Sample Components

April 19, 2012
Frank Steiner

,
David Thomas

,
Felicity Kusinitz

,
Rainer Bauder

The Column

The Column, The Column-04-19-2012, Volume 7, Issue 8
Page Number: 15–19

LC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?

LC method development for new drug candidates or screening methods for new active structures in botanicals present the same type of challenges: How do I know that I have separated all main components, as well as important, sometimes hidden, impurities? Is my resolution good enough? Am I missing small, co-eluting peaks?

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