The Column-06-06-2017

June 06, 2017

High quality, low cost is a standard mantra within the pharmaceutical industry, but with increasing structural complexity of drugs and drug candidates maintaining the core value of this mantra is becoming more difficult. Kanta Horie from Eisai Co., Ltd., recently spoke to The Column about the development of an intelligent peak deconvolution technique using multivariate curve resolution-alternating least squares (MCR-ALS) that allows accurate quantitation of multiple components with different absorbing spectra even if the peaks are not completely separated.

June 06, 2017

hermo Fisher Scientific has announced its intention to buy Patheon NV.

June 06, 2017

A novel unit that integrates sampling and analysis for the determination of pest insect sexual pheromones in environmental air using fabric phase sorptive extraction (FPSE) and headspace gas chromatography coupled to mass spectrometry (HSGC–MS) has been developed at the University of Córdoba in Spain.

June 06, 2017

MilliporeSigma is now accepting entries for the Alfred R. Bader Award for Student Innovation.

June 06, 2017

Peak Scientific has expanded its operations in Latin American (LATAM), moving to a new, larger premise with the aim of developing its support capabilities in the growing LATAM market.

June 06, 2017

Molecular mass is one of the central parameters required for product registration. Compared to low molar mass substances, the molar mass determination of macromolecular products is more difficult because the product is a mixture of chains with different lengths and, therefore, molar masses. Gel permeation chromatography/size-exclusion chromatography (GPC/SEC) is the standard technique to separate macromolecules by size and to measure the complete molar mass distribution as well as the molar mass averages. This technique therefore provides crucial information for product registration, including REACH.

June 06, 2017

A preview of HPLC 2017, which will be held from 18 to 22 June 2017 at the Prague Congress Centre, Prague, Czech Republic.

June 06, 2017

Analysis of residual antimicrobials in animal products is crucially important to ensure food safety. This article presents a simple, fast, and highly sensitive high performance liquid chromatography (HPLC) assay of regulated antimicrobials, as well as sample preparation and purification methods. Twenty-four different analytes of interest were investigated in beef, pork, and chicken meat samples.

June 06, 2017

Successful therapeutic intervention often requires chiral medicines because of the intrinsic chirality of protein drug targets, which consist of L-amino acids. Potency, efficacy, and safety can be highly dependent on the precise stereochemical geometry of the molecules. Determining the biological profile of individual enantiomers in the early stages of drug discovery is important for successful optimization towards clinical candidates. Here we demonstrate the benefits of supercritical fluid chromatography (SFC) with three chiral stationary phases exemplified by high frequency resolution of 41 out of 50 chiral derivatives of eight commonly used drug discovery scaffolds including 1,3-thiazoles, 1,3-benzothiazoles, pyranoquinolones, indoles, and leucolines.

June 06, 2017

A preview of the HPTLC 2017 symposium, which will take place this July.

June 06, 2017

Click the title above to open The Column June 06, 2017 Europe & Asia issue, Volume 13, Number 8, in an interactive PDF format.

June 06, 2017

Click the title above to open The Column June 06, 2017 North American issue, Volume 13, Number 8, in an interactive PDF format.