The Column-09-04-2014

Saliva is becoming ever more commonly used in drug testing over urine or blood samples because of its ease of collection. As such, existing testing methods are being adapted for application to accommodate a change in sample matrix. In a new study published in the Journal of Chromatography A, scientists from the National Institute on Drug Abuse (Maryland, USA) and the University of Maryland Baltimore (Maryland, USA) present the use of precolumn derivatization using N(?)-(2,4-dinitro-5-fluorophenyl)-l-alaninamide (Marfey?s reagent) prior to liquid chromatography–mass spectrometry (LC–MS) analysis for the quantitation of chiral amphetamines in plasma and saliva.1

The Column spoke to Tony Edge of Thermo Fisher Scientific about the development of a new type of stationary phase based on fractal-shaped particles.

LCGC Blogger Tony Taylor provides his impartial guide to liner selection that is representative of the considerations in modern capillary gas chromatography (GC).

This article describes a simple, more convenient method than traditional solid-phase extraction (SPE)-based methods for highly sensitive PPCP detection using triple quadrupole liquid chromatography–mass spectrometry (LC–MS–MS).

Ultrahigh-pressure liquid chromatography (UHPLC) columns are used in peptide mapping to improve the resolution of highly complex peptide mixtures. It is commonly assumed that small particle columns increase performance, but this is not always the case. This study presents a comparison of peak count, column length, and resolution between core–shell and fully porous UHPLC columns.

Waters Corporation and PSS GmbH have announced the return of the International GPC/SEC Symposium to be held at The Westin Grand Frankfurt Hotel in Frankfurt, Germany, on 30 September–2 October 2014.

A team of scientists from the University of Muenster and the University of Siegen in Germany has demonstrated the use of low temperature plasma desorption/ionization orbitrap high-resolution mass spectrometry (LTP–Orbitrap–HR–MS) for the analysis of pesticide residues in fruit.

Click the title above to open The Column September 08, 2014 North American issue, Volume 10, Number 16, in an interactive PDF format.

Click the title above to open The Column September 04, 2014 Europe & Asia issue, Volume 10, Number 16, in an interactive PDF format.