The Column-12-10-2019

Issue PDF
The Column

December 10, 2019

Click the title above to open The Column December 2019 Europe & Asia issue, Volume 15, Number 12, in an interactive PDF format.

Click the title above to open The Column December 2019 North American issue, Volume 15, Number 12, in an interactive PDF format.

The Column

The Eastern Analytical Symposium (EAS) Award for Outstanding Achievements in Chemometrics was presented to Peter de Boves Harrington on Tuesday 19 November.

Instrumental Innovations 2019
The Column

December 10, 2019

Selected highlights of innovative chromatography products.

Researchers from the University of Leipzig have used gas chromatography–mass spectrometry (GC–MS) to study the fertility cues of non-human primates.

The Column
News

December 10, 2019

The Eastern Analytical Symposium (EAS) Award for Outstanding Achievements in the Fields of Analytical Chemistry was presented to Joel M. Harris at EAS 2019 on Wednesday 20 November.

The Column

LCGC is proud to announce that Daniel W. Armstrong and Szabolcs Fekete are the winners of the 13th annual LCGC Lifetime Achievement and Emerging Leader in Chromatography Awards, respectively.

Thermo Fisher Scientific has announced a collaboration with Owlstone Medical to advance the early diagnosis of cancer and other diseases utilizing novel biomarkers and non-invasive breath sampling.

The Column

What does a best-in-class laboratory workplace look like?

Partial coelution of chromatographic peaks is an often-encountered issue in high performance liquid chromatography (HPLC) analysis, despite best efforts in method development and optimization. Even though there are several ways of integration of overlapping signals, accurate quantification of single compounds using conventional photodiode array (PDA) detection is almost impossible without baseline separation. While extensive signal processing is well established in spectroscopic analyses such as infrared (IR) or nuclear magnetic resonance (NMR), it has not yet been commonly adapted to improve chromatographic data evaluation. This article introduces the theory and application of a novel data analysis technique for PDA detection to accurately determine and quantify single compounds, even from overlapping peaks, without the need for mass spectrometry (MS) detection.

The “greenest solution” is certainly using no solvent but gel permeation chromatography/size-exclusion chromatography (GPC/SEC) as a liquid chromatography (LC) technique requires the use of a mobile phase. The growing awareness of the need for more sustainable (greener) solutions has focused attention on environmentally- and health-friendly solvents and solutions.

The Column
Features

December 10, 2019

To fully characterize a protein biopharmaceutical, it must be broken down into smaller segments (peptides). Several high performance liquid chromatography (HPLC) techniques can be used to provide a wealth of information on everything from post-translational modifications (PTMs) to the glycoprofile to information on similarity when characterizing biosimilars.