LCGC Europe-11-01-2004

In this month's column the authors present a case study to outline several gradient quality checks that can be performed periodically to ensure proper performance of LC instrumentation. The example shows how by taking the time to perform such tests, potential problems can be identified before they reach a critical point.

In this article, the authors present a column ranking system to facilitate column selection in reversed-phase liquid chromatographic analysis. The system ranks columns based on their similarity to a reference column of choice and its applicability to a real pharmaceutical analysis is demonstrated.

This instalment of GC Connections examines the basics of peak identification and quantification and demonstrates how they can both influence the quality of one's results as much as or even more than sample preparation, separation and detection.

In this, the first of a two-part series, the authors provide some background on the PCA method and introduce some of the terminology used by practitioners of the method.

A new sampling method for gas chromatography termed single-drop microextraction (SDME) is described. In this column, SDME is applied to residual solvent analysis, both in manual and automated modes.