LCGC Europe-11-01-2020

Not (Only) Reversed-Phase Liquid Chromatography–Mass Spectrometry: Alternative LC–MS Approaches

November 01, 2020

Cover Story

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Reversed-phase LC–MS has limitations in numerous analytical applications. Alternative MS-compatible chromatographic techniques separate analytes in the liquid phase based on different retention mechanisms compared with reversed-phase LC. This article describes these alternative chromatographic approaches, relevant applications, and the future of these techniques.

Troubleshooting for Two-Dimensional Liquid Chromatography: Breakthrough in the Second Dimension

November 01, 2020

LC Troubleshooting

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A common problem encountered in the development of 2D-LC methods is that the first dimension mobile phase properties can negatively affect the quality of subsequent second dimension separations. This installment reviews the origin of this problem and discusses potential solutions.

Exploring the Efficiency of Various Extraction Approaches for Determination of Crude MCHM Constituents in Environmental Samples

November 01, 2020

Sample Preparation Perspectives

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It is important to develop analytical methods to detect crude MCHM components in environmental water samples. This article describes two microextractive methods based on solid-phase microextraction (SPME) in fibre format and thin film microextraction (TFME) that were developed and validated for 4-MCHM and other constituents of crude MCHM.

Control or Chaos: How Can We Run a Gas Chromatograph from Anywhere?

November 01, 2020

GC Connections

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This instalment explores how the data system controls the functions of the GC instrument. Drawing on classical electronics and instrument designs, the article describes the evolution of instrument controls from knobs and gauges on the front panel of the instrument to computer control and current web-based systems.

What’s Good About the WHO Good Chromatography Practices Guidance? Part 1

November 01, 2020

Questions of Quality

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In September the World Health Organisation (WHO) issued a new guidance document on Good Chromatography Practices. What guidance does it contain and is it useful? Has the document failed its SST acceptance criteria?