LCGC Europe-12-01-2006

LCGC Europe

Experimental Proofs of a Correlation Between the Coefficients for the Slope of the Response Line and the Response Factor of an ELSD

December 01, 2006

Evaporative Light Scattering

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The authors describe a study that was conducted to evaluate the correlation between the slope of the response line and the response factor of an ELSD that are ordinarily regarded as independent numerical coefficients.

All round vision

December 01, 2006

New Technologies

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In the June 2006 issue of LCGC Europe we featured a display wall that may be the future for molecular modelling. Here we preview another possibility - an interesting helmet from electronics manufacturer Toshiba that enables the wearer to experience a full 360? view on a 40 cm dome-shaped screen. The full-faced helmet, known as the Head Dome Projector, weighs 3 kg and exhibits a wide viewing angle of 120? horizontally by 70? vertically without head tracking and 360? ? 360? with head tracking.

Making Connections

December 01, 2006

LC Troubleshooting

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Sometimes it is easy to ignore the fittings and tubing that are used to connect various parts of the liquid chromatography (LC) system. After all, it's the pump, injector, column and detector that do all the work - right? Well, yes and no. It is possible to compromise an otherwise excellent separation by the improper use of fittings, but with reasonable care, you should not have problems with most applications. This month's instalment of "LC Troubleshooting" takes a look at the important components that are used to connect various parts of the LC system and how to use them wisely.

How Close is Close Enough? Accuracy and Precision

December 01, 2006

GC Connections

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The accuracy and precision of results in gas chromatography and other analytical techniques are highly dependent upon the sample and its preparation, the instrumentation, accessories and operating conditions, as well as on operator skill and experience. For these reasons, accuracy and precision for a specific methodology can be expected to vary from one laboratory or operator to another. This month, we look at statistical analysis as a diagnostic tool.

Data-Handling Software for a GLP Environment: Development and Validation Requirements

December 01, 2006

Practical Data Handling

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In a good laboratory practice (GLP) environment, data-handling software cannot be used until it is validated. This even applies to the most simple program that performs calculations or stores data. A detailed documentation of the set-up and the performance of the software - called software validation - is required. The development and validation requirements are described in this article and illustrated with a software for robustness testing (SRT), which guides the user step-by-step through the experimental set-up and interpretation of robustness tests. This software was developed in an Excel (Windows XP) environment and is used as part of method validation in laboratories that require compliance with GLP and 21 CFR Part 11. The software was subjected to software validation regulations and is compliant with electronic records and signature rules (21 CFR Part 11) as it creates, delivers and stores electronic data. The validation tests are based on the computerized system validation (CSV) -..

European headquarters' relocation

December 01, 2006

News

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Velocity11 has announced the relocation of its European headquarters to larger purpose built offices in the UK. This move reflects the company's successful product introductions and an increase in installed systems during the last 18 months.

The Benefits of Including Certified Reference Materials in a Collaborative Trial

December 01, 2006

Food Analysis

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This article assesses the advantages of including certified reference materials in collaborative method validation studies in food analysis. A recently conducted collaborative trial on the determination of acrylamide in bakery and potato products is described to illustrate this.