March 2021 | LCGC Europe

Next-Gen Sorbent-Based Extractions with Metal-Organic Frameworks

March 11, 2021

Columns

34

3

A review of cutting-edge analytical extractions using metal-organic frameworks (MOFs), including a description of what MOFs are, their preparation, principles of use, advantages, and application areas.

Hydrophobic Interaction Chromatography (HIC) for the Characterization of Therapeutic Monoclonal Antibodies and Related Products, Part 1: Theoretical Aspects

March 11, 2021

Cover Story

34

3

A review of the current state of HIC, focusing on retention and separation mechanisms with the aim of developing more robust methods. Can HIC be considered as a non-denaturing and non-destructive technique with advantages for protein analysis?

Non-aqueous Ion-Exchange Chromatography Using High Acid-base Concentration: A Strategy for Purifying Non-crystalline Pharmaceutical Intermediates

March 11, 2021

Peer Reviewed

34

3

Ion-exchange chromatography (IEX) is a frequently overlooked technique. This novel IEX method uses non-aqueous mobile phases to purify a non-crystalline intermediate after a reductive amination with D-xylose. IEX delivers a step change in strength and purity of the intermediate allowing successful downstream processing.

Surfing on Mobile Phase, Part 2: Impact of Mobile Phase Composition Waves on Retention in LC

March 11, 2021

Columns

34

3

How do the characteristics of the mobile phase waves and retention properties of an analyte of interest impact retention precision?

Let’s Get Small - Powerful Gas Chromatography in Small Packages

March 11, 2021

Columns

34

3

With full laboratory capability now available in smaller systems, the possibilities for rethinking our use of gas chromatography (GC) both inside and outside the laboratory are (almost) endless.