January 2000

Guest author Paul Ross explains why porous graphite carbon may provide a solution to certain specific challenges in the retention and separation of very polar analytes and structurally similar compounds.

Most chromatographers can look at a chromatogram and provide a qualitative opinion about the separation, but it is equally important to be able to measure the separation quality.

By adopting standard buffers, analysts can gain a great deal of operating efficiency and significantly reduce method development and validation costs.

In this first installment of this new column, editor Tim Wehr explores the evolution of drug discovery and the analytical challenges that lie ahead.

Despite their different levels of technological maturity, CE and LC coupled with electrospray ionization MS techniques can be operated at the same level of automation. However, they differ in their configuration, selectivity, sensitivity, and method development.

Part I of this series of articles provides an overview of a chromatography data system, including the life cycle, key functions, and problems.