LCGC-11-01-2020 | LCGC North America

How Can We Run a Gas Chromatograph from Anywhere?

November 01, 2020

GC Connections

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Computers control all aspects of modern GC instrument operation, from temperature to valve actuation. We look under the hood to see how this works.

Troubleshooting for Two-Dimensional Liquid Chromatography (2D–LC): Breakthrough in the Second Dimension

November 01, 2020

LC Troubleshooting

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In 2D-LC, properties of the mobile phase used in first step can negatively affect the second step. We explain why this problem happens and how to avoid it.

Ion Mobility Spectrometry (IMS): How It Works and Its Use in Biotechnology

November 01, 2020

Focus on Biopharmaceutical Analysis

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IMS is a valuable tool for biopharmaceutical analysis. Two formats in particular have proven useful: cyclic IMS and structures for lossless manipulations (SLIM).

Validation of Stability-Indicating HPLC Methods for Pharmaceuticals: Overview, Methodologies, and Case Studies

November 01, 2020

Perspectives in Modern HPLC

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In the pharmaceutical industry, method validation is essential. But what are the best practices? We review regulatory requirements, validation parameters, methodologies, acceptance criteria, trends, and software tools.

The Importance of Corporate Culture in Ensuring Data Integrity

November 01, 2020

Focus on Data Handling

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Data systems are important in ensuring data integrity, but what should laboratories do beyond looking at data systems—with respect to people, processes, and culture? To understand more, we spoke to Mark Newton, of Heartland QA, in Lebanon, Indiana, in a podcast interview.

Comparing Scientific Marketing to Analytical Reality

November 01, 2020

Featured Article

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Consumer marketing approaches are creeping into the marketing of scientific instruments. With a careful approach, you can cut through the hype.

Effects of Sample Diluents and Sample Matrices on Residual Solvents in Pharmaceuticals Analyzed with Static Headspace Gas Chromatography

November 01, 2020

Peer-Reviewed Article

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In static headspace gas chromatography (HS-GC) sample diluents and sample matrices can affect analytical method sensitivity, accuracy, and interferences. By applying the rules revealed by this study, these problems can be avoided.