LCGC North America-02-01-2014

Quality-by-design principles are applied to build in a more scientific and risk-based multifactorial strategy in the development of a UHPLC method for analyzing a drug and its related impurities.

The selective removal of a fat substitute in food products is discussed to demonstrate options for obtaining selectivity during extraction.

Key considerations for setting up or troubleshooting a GC method.

A discussion of the future role of miniature MS systems, the need for simplification in operation, the role of ambient ionization, and challenges in development and commercialization.

The analysis of pesticide residues in food samples from the state of Connecticut's regulatory monitoring program are compared to USDA and US FDA results.

What kind of adjustments need to be made when scaling an isocratic method?

The National Institute of Standards and Technology (NIST).

Click the title above to open the LCGC North America February 2014 regular issue, Vol 32 No 2, in an interactive PDF format.