LCGC North America-05-01-2006

Globally, 2005 sales of pharmaceuticals have been estimated at approximately $550 billion. A significant fraction of this amount was due to the top pharmaceutical companies in the world. The top five companies alone were responsible for total revenues of $168 billion, or 30% of the entire market.

In this tutorial, the mechanism and origin of ion suppression will be investigated, as well as ways to validate the presence, and circumvent or compensate for, the effects in LC-MS.

In his annual installment, John Hinshaw takes a look at the new gas chromatography instruments and accessories that were on display at Pittcon this year.

This is the second installment of a two-part series on the practical aspects of configuring and operating a nano liquid chromatography-mass spectrometry (LC-MS) system.

Guest columnist Walter Jennings reflects on the early days of capillary gas chromatography (GC) and how chromatographers become experts in the technology by constructing their own columns, thereby achieving a more thorough understanding of the chromatographic process.

Water and Bruker annouce collaboration Millipore increases investments in international markets Grace opens center in Shanghai ACD/Labs, Applied Biosystems, and MDS SCIEX sign agreement

The authors define robustness, instroduce a few approaches to designing a robustness study, and discuss data analysis necessary to help ensure successful method implementation and transfer as a part of method validation protocol.

John Dolan delves deeper into dwell volume, a subject that was touched upon in a recent installment of "LC Troubleshooting."