LCGC North America-08-01-2012

Smaller particles, increasingly clever ways to overcome mass transfer limitations, further reductions in plate height, shorter separation times, higher pressure, and enhanced peak capacity dominate thinking in the high performance liquid chromatography (HPLC) community today. For healthcare applications, however, we need to think differently about how to improve analytical separations.

In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts (listed in the sidebar) to assess the current state of the art of liquid chromatography (LC) column technology, and to try to predict how the technology will develop in the future. This article is part of a special group of articles covering the state of the art in sample preparation, gas chromatography (GC) columns, GC instrumentation, LC columns, and LC instrumentation.

Problems with retention-time drift, temperature control, and broad peaks from a new column are discussed.

Milestone events, like LCGC's celebration of 30 years of covering separation science, always prompt reflection on the past and consideration of what the future might hold. Thus, for this 30th anniversary issue, we turned to the experts in five key areas of our coverage: sample preparation, gas chromatography (GC) columns, GC instrumentation, liquid chromatography (LC) columns, and LC instrumentation. Now, in the special group of five articles in this issue, we bring you their perspectives on the state of the art: what the most important recent advances have been, where things stand today, and where the field is likely to go next.

In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts (listed in the sidebar) to assess the current state of the art of gas chromatography (GC) instrumentation and to try to predict how the technology will develop in the future.

LCGC's global online presence is an ever-growing aspect of this publication as we strive to bring our readers the knowledge they need in a timely manner.

An alternative approach to liquid–liquid extraction is explored.

Ion-exchange chromatography (IEC) is based on the different affinities of analyte and eluent counterions for the oppositely charged ionic functional groups on the stationary-phase surface of an exchange resin. Depending on the charge of the surface electrostatic groups, the resin could be either an anion exchanger (positively charged stationary phase) or a cation exchanger (negatively charged stationary phase).

In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts (listed in the sidebar) about the current state of the art of high performance liquid chromatography (HPLC) instrumentation and how the technology will develop in the future.

An overview of applications of various types of MS systems in drug discovery efforts, including in vitro and in vivo screening assays.

In honor of LCGC's celebration of 30 years covering the latest developments in separation science, we asked a panel of experts to assess the current state of the art of gas chromatography (GC) column technology, and to try to predict how the technology will develop in the future.

Congratulations, LCGC, on 30 successful years of reporting on the current trends in chromatography. Certainly, this is an accomplishment that we in the separations community have enjoyed and benefited from, and we wish you many more happy years of success.

Click the title above to open the LCGC North America August 2012 regular issue, Vol 30 No 8, in an interactive PDF format.