Hot Topics in Mass Spectrometry

Non-targeted analysis of small molecules with ambient ionization mass spectrometry (AI-MS) is enabled by new mass spectral libraries and algorithms, such as the inverted library search algorithm (ILSA) developed at NIST.

Are generic workflows really needed in environmental analysis? In the end, it is the analyst— not instrumentation or software—that is in charge of what data are obtained, after thoughtfully considering what sample preparation and acquisition method to use.

Gene therapy vectors in the gigadalton (GDa) regime are beyond the range of conventional mass spectrometry. Charge-detection MS overcomes this limitation.

Extracting thousands of metabolomics features from LC–MS–based metabolomics data is not easy. A new suite of free bioinformatics tools helps address these metabolic peak-picking challenges and thus obtain more accurate biological information.