Recent Developments in Sample Preparation

New approaches to sample preparation are being developed for microbial metabolomics to address the inherent complexity of this type of analysis.

Analytical scientists are following a number of trends in method development to make sample preparation both simpler and more sustainable.

Reducing matrix effects during LC–MS/MS bioanalysis is paramount. Improving sample preparation techniques is the best way to combat this issue.

Microextraction techniques have evolved since their appearance three decades ago, moving toward the use of greener and sustainable materials and solvents.

Recent developments in microextraction automation has resulted in more straightforward workflows.

Multiple-cumulative trapping headspace extraction coupled with high-concentration-capacity tools, such as SPME, enhances sensitivity of volatiles, as illustrated here in food analysis.

Ionic liquids (IL) are a very versatile tool for natural product and food analysis. When combined with moieties with different functional groups, ILs can be tuned to obtain extraction media with different properties and selectivity.