Rigid Porous Polymer Monoliths as Stationary Phases and Supports
April 01, 2008
The never-ending quest for separation media that enable efficient high speed/high throughput chromatography has led to the design of stationary phases in monolithic formats with both vastly improved mass transfer properties and reduced discontinuity. Historically, porous polymer monoliths have first emerged in the late 1980s/early 1990s followed by their silica-based counterparts in the mid 1990s. The common denominator for both organic and inorganic monoliths was originally their use in HPLC columns. However, the range of applications of monolithic materials grew significantly since their early times. This short review summarizes information about monoliths produced in different shapes such as discs, tubes, columns, polymer layer open tubes (PLOT capillaries), and microfluidic devices, and presents selected applications including chromatographic separations, sample preparation, and enzyme immobilization.