A new “one-shot” strategy for preparative chiral supercritical fluid chromatography (SFC) offers fast and effective approach to obtain and characterize individual enantiomers.

SFC delivers measurable cycle-time and solvent-use gains beyond chiral work, spanning biopharma and anti-doping applications, experts say.

Karine Faure discusses how SFC with alternative solvents could offer a more sustainable path forward for liquid chromatography separations.

Daniel W. Armstrong explains how SFC confirmed mirror-image ruthenium photosensitiz-ers perform identically against melanoma cells.

Kevin Schug explains how surrogate optimization streamlines SFE–SFC–MS method development, achieving R² values up to 0.97 while boosting sensitivity by 15%

LCGC International spoke to Cristian Reale about an eco-friendly SFC-PDA method that rapidly measures furocoumarins in Citrus essential oils.

In preparative chiral supercritical fluid chromatography (SFC), adding 2.5–5% water cuts retention times and narrows collection windows, boosting throughput.

Princeton Chromatography's Jeff Caldwell says SFC can now complete separations in 10–15 seconds.