Analytica 2024: An Interview with Sebastiaan Eeltink

At Analytica 2024 in Munich, Germany, LCGC International sat down with Sebastiaan Eeltink of Vrije Universiteit Brussel to talk about the three-dimensional liquid chromatography (3D–LC) separations.

Eeltink is a Full Professor at Vrije Universiteit Brussel and Editor of Analytical Science Advances at Wiley. He is the lead investigator of the Eeltink Laboratory at Vrije Universiteit Brussel. The Eeltink Laboratory focuses on developing and designing novel analytics for the high-resolution profiling of biomolecules and biomolecular interactions using ultrahigh-pressure liquid chromatography (UHPLC) and multi-dimensional liquid chromatographic workflows with mass spectrometry (MS) detection.

The Eeltink Lab also manages the VUB proteomics platform which offers high-performance LC-MS proteomics profiling expertise and advise to academic and industrial collaborators.

In this interview segment, Eeltink answers the following questions:

• Can you explain the concept of spatial 3D–LC?
• What were the technological challenges you addressed when developing the 3D–LC chip?
• What are the applications you are pursuing with 3D–LC?
• How did you detect the analytes?
• Have you compared spatial 3D–LC to current 1D–LC and 2D–LC methods?