Applications of Field-Flow Fractionation in Drug Delivery Analysis

August 20, 2020
Postnova

Sponsored Content

Size, mass, and the aggregation state of your drug delivery particle matter! This webinar will present four unique applications of field-flow fractionation (FFF) in the characterization of different types of drug delivery systems. Monday, Sept. 28, 2020 at 9am EDT | 2pm BST | 3pm CEST On demand available after final airing until Sept. 28, 2021.

Register free: http://www.chromatographyonline.com/lcgc_w/delivery_analysis

Event Overview:

This webcast demonstrates that field-flow fractionation (FFF) interfaced with multi-angle light scattering (MALS) and other detectors is an ideal tool for characterization of different drug delivery systems, including liposomes and adeno-associated viruses. In particular, we will discuss how:

  • Properties like size and surface charge of liposomal doxorubicin can be measured by electrical asymmetrical flow FFF interfaced with a MALS detector in the course of few runs
  • Different serotypes of adeno-associated viruses (AAV) and their aggregation behavior when they are exposed to heat can be studied using asymmetrical flow FFF-MALS
  • Centrifugal FFF can be used to measure the mass difference between empty and filled liposomes
  • Centrifugal FFF coupled to MALS can measure liposome density by measuring its mass and size simultaneously in a single run

Key Learning Objectives:

  • How electrical asymmetrical flow FFF works, and how it can reveal information about size and surface charge of liposomal drug delivery systems
  • How different AAV serotypes aggregate when they are exposed to heat, and how flow FFF can separate aggregates and fragments from monomers
  • How centrifugal FFF works, and how it can measure masses of empty and drug-loaded liposomes

Speaker: Dr. Soheyl Tadjiki, Managing Director, Postnova USA

Time and Date: Monday, Sept. 28, 2020 at 9am EDT | 2pm BST | 3pm CEST

On demand available after final airing until Sept. 28, 2021.

Sponsor: Postnova

Register free: http://www.chromatographyonline.com/lcgc_w/delivery_analysis