Restek Corporation | Authors

A fast, direct method for LC–MS/MS analysis of amino acids in plasma was developed during the course of this study.  

Using a mass spectrometer as a gas chromatography (GC) detector has many advantages for compound identification and quantification, but there is another less-known benefit: speeding up analyses by using the mass spectrometry (MS) vacuum to lower pressure within the column. This technique, also known as “vacuum‑outlet GC” or “low-pressure GC–MS” (LPGC–MS), can provide significant gains for fast GC–MS.

LPGC–MS is a technique that uses the MS vacuum system, along with a specially designed column setup, to lower pressure inside the entire column, speeding up analysis.