Liquid chromatography–ion mobility spectrometry–high-resolution mass spectrometry (LC–IMS–HRMS) shows elephant seal pups carry more PFAS than their mothers do.
News|Articles|July 1, 2026
ASMS 2026: Yifan Liu and the Need for a Dedicated LT-ZIC-HILIC Retention Time Library
Author(s)Yifan Liu, Jerome Workman Jr.
Key Takeaways
- A dedicated LT‑ZIC‑HILIC retention-time library can strengthen metabolite ID confidence in LC–MS workflows by pairing low-temperature separations with standardized retention information.
- Coverage of 471/600 metabolite standards indicates substantial library robustness and suggests feasibility for broad metabolomics applications and inter-study harmonization.
In the third of this four-part series, Yifan Liu of Northeastern University (Boston, MA) discusses the a need for dedicated LT-ZIC-HILIC retention time library for metabolic research.
Advertisement
LCGC International spoke to Yifan Liu of Northeastern University (Boston, MA) regarding her presentation, Low-Temperature HILIC Provides Enhanced Separations and Stability for LC–MS-Based Metabolomics.
Here, Liu weighs in on the need for dedicated LT-ZIC-HILIC retention time library for metabolic research.
“In our most recent work, we already built our LT-ZIC-HILIC library, which identifies 471 out of 600 metabolite standards, so it is quite robust. As for retention-time drift, we applied LT-ZIC-HILIC on another instrument…and found that LT-ZIC-HILIC still outperformed the standard method. We did observe a retention-time shift, but this wasn’t due to the method itself; it was because that instrument is limited to a flow rate of 0.1 mL/min, whereas our optimal flow rate is 0.15 mL/min. So I believe the retention-time shift is due to flow-rate limitations of the instrument, not the method.”
Advertisement
Related to this article
Gas chromatography–mass spectrometry (GC–MS) and omics profiling distinguish duck and goose foie gras composition.
This week's Chromatography Online highlights include olive waste antioxidant recovery, food and tea analysis, EV isolation, mRNA vaccine purification, perfusion chromatography for oligonucleotides, mass spectrometry in teaching and career advice from “Women in Chromatography.”
Kinjal Bhatt and Ina Varfaj call AI a chromatography equalizer only if training and access keep pace, framing the risk as implementation, not technology.
Gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS) reveal lasting brain cholesterol loss after myelin damage.
Metrohm USA's IONIC Titrator offers cloud access and a 10-inch touchscreen.
Chromatography and spectrometry were used in tandem to reveal how ultrasound boosts chicken soup flavor compounds.
Kinjal Bhatt would expose early-career scientists to the field sooner, while Ina Varfaj says a broken chromatography column taught her failure is normal.
Advertisement
Advertisement