Basic Analyte Blues? Elevate Your Separations of Basic Compounds at High pH Using New Column Chemistry



Webinar Date/Time: Airing 1: Thursday, May 30, 2024 at 11am EDT | 12pm CDT | 8am PDT Airing 2: Friday, May 31, 2024 at 11am CST (Chinese Standard Time) | 12pm JST | 1pm AEST

Learn about a new high pH stable LC column phase built on superficially porous particle technology that can improve the chromatography of basic compounds. Example applications of small molecules and oligonucleotides as well as stability data will be highlighted.

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Event Overview:

LC and LCMS methods run at elevated pH show advantages in terms of retention and peak shape symmetry for basic analytes. A new high pH stable silica phase designed on superficially porous particle technology enables separation methods using both elevated pH and temperature. Comparative stability data and application examples showing how chromatography improves when moving from low pH to high pH conditions will be presented for small molecule analytes and oligonucleotides.

Key Learning Objectives:

  • Improve the peak shape and retention of basic compounds by using a high pH stable SPP column.
  • Understand the advantages of pH as a method development lever.
  • Learn about the column options for analyzing basic analytes based upon selected pH.

Who Should Attend:

  • Scientists developing LC and LCMS methods
  • Lab managers
  • Chromatographers

QA/QC managers


Stephanie Schuster, Ph.D.
Senior Technical Support Scientist
Advanced Materials Technology

Beginning in June of 2009, Dr. Stephanie Schuster joined Advanced Materials Technology, Inc. (AMT) located in Wilmington, DE as a research scientist working with Dr. Jack Kirkland. In this position, Dr. Schuster provided contributions to the commercial development of products specifically designed for the separation of peptides and proteins. During the summer of 2015, Dr. Schuster transitioned from research and development activities to applications development and quality assurance. She is currently a senior technical support scientist at AMT. As such, Dr. Schuster works closely with AMT’s worldwide network of distributors and assists customers with optimizing and trouble-shooting their applications. Her primary interests are separations and novel materials development. Dr. Schuster has several peer-reviewed articles and is currently a member of the Chromatography Forum of the Delaware Valley.

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