Creating Greener HPLC Methods as Measured by the AMGS Metric: A Case Study of Improving USP Monograph Methods

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HPLC is a versatile and widely used method for analyzing various compounds, particularly in the pharmaceutical industry. It's preferred by generic pharmaceutical companies and quality control groups due to its accessibility compared to newer technologies like Ultra-Performance Liquid Chromatography (UPLC™). In recent years, there has been a growing emphasis on making analytical chemistry techniques, such as HPLC, more sustainable. These "green" initiatives aim to reduce the use of toxic reagents, minimize waste, and lower energy consumption, all while maintaining high scientific standards. This app note highlights Development of a new, greener HPLC method for rivaroxaban and impurities, aligned with the USP monograph and using the Analytical Method Greenness Score (AMGS).