Critical Pairs in Column Chromatography: A Primer for Pharmaceutical Method Validation

Florian Geistmann succeeded retiring Jürgen Semmler as Shimadzu Europa managing director on October 1.

Liquid chromatography-mass spectrometry (LC-MS) profiling reveals chemical diversity across grapevine varieties.

Liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) link perinatal factors to infant urinary metabolite changes.

This LCGC Blog installment explains how NIST categorizes and certifies reference materials, and why they underpin reliable results in science and medicine.

Comparing manual and automated N-glycan profiling of a trastuzumab biosimilar, researchers found that both workflows detected the same glycan types, but automation gave more reproducible results (mean CV of about 5.7% vs. 7.95%), making it better suited to high-throughput analysis in biopharmaceutical development.

How can analysts resolve impurities that differ by a single mass unit? Experts discuss deamidation, racemization, HRMS, and 2D-LC for GLP-1 peptides.

"LC Troubleshooting" explores why phosphorothioate oligonucleotides (ONs) diastereomers challenge liquid chromatography.

This new high-performance liquid chromatography (HPLC) method reliably measures cholesterol adsorption in artichoke fiber.