Cytotoxic leaves

March 28, 2011

A chromatographic study of extracts from the leaves of a Calomeria amaranthoides has found potent anti-cancer effects against ovarian cancer cells.

A chromatographic study of extracts from the leaves of a Calomeria amaranthoides has found potent anti-cancer effects against ovarian cancer cells.

The scientists from the universities of Sydney, Australia and Leiden, The Netherlands, and the Reinier de Graaf Group of Hospitals in Delft, The Netherlands extracted and fractionated the leaves using column chromatography. Tests were performed on the extracts and on isolated compounds on ovarian cancer cell lines.

According to the study two compounds were isolated by chromatographic fractionation and identified by 1H-NMR, 13C-NMR and mass spectrometry analyses. These were EPD, an alpha-methylene sesquiterpene lactone of the eremophilanolide subtype, and EPA, an alpha-methylene carboxylic acid.

The study concluded that both crude plant extracts from Calomeria amaranthoides and EPD have shown to have potent anti-cancer affects against ovarian cancer, while EPA had no cytotoxic effects.

The full study is available from the Journal of Experimental and Clinical Cancer Research at http://www.jeccr.com/content/30/1/29

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