Hot Topics in PFAS (Sept 2025)

Hot Topics in PFAS” from LCGC International, we provide a comprehensive overview of per- and polyfluoroalkyl substances (PFAS) analysis, highlighting the evolving analytical techniques, challenges, and regulatory landscape surrounding these persistent chemicals. Key analytical challenges, such as matrix effects, sample contamination, and the lack of commercial standards, are addressed, alongside innovations like matrix-matched semiquantification for complex samples and the use of specialized HPLC columns to retain ultra-short-chain PFAS.