Hot Topics in PFAS” from LCGC International, we provide a comprehensive overview of per- and polyfluoroalkyl substances (PFAS) analysis, highlighting the evolving analytical techniques, challenges, and regulatory landscape surrounding these persistent chemicals. Key analytical challenges, such as matrix effects, sample contamination, and the lack of commercial standards, are addressed, alongside innovations like matrix-matched semiquantification for complex samples and the use of specialized HPLC columns to retain ultra-short-chain PFAS.
This LCGC Blog installment explains how NIST categorizes and certifies reference materials, and why they underpin reliable results in science and medicine.
Comparing manual and automated N-glycan profiling of a trastuzumab biosimilar, researchers found that both workflows detected the same glycan types, but automation gave more reproducible results (mean CV of about 5.7% vs. 7.95%), making it better suited to high-throughput analysis in biopharmaceutical development.