A fast and easy-to-use method for the identifcation and determination of active anionic ingredients in toothpaste is presented using ion chromatography in combination with electrospray mass spectrometry. In this application, positive identification of glycerol, sorbitol, chloride, fluoride, sulphate, monofluorophosphate and polyphospates, in addition to citrate and saccharin, is achieved in one chromatographic run with a total analysis time of 22 min.
In this eighth part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses why ultraviolet detection dominates pharmaceutical analysis and quality control.
High-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS) was used in a reverse triiodothyronine (rT3) test to separate canine hypothyroidism from illness.
Quantera Analytical’s Terry Bates discusses parallel headspace extraction for gas chromatography-mass spectrometry (GC–MS) and direct analysis in real time–mass spectrometry (DART–MS) analysis.
Amandaa Brewer warns a shortage of large-molecule chromatography experts, as practitioners retire, could leave the next generation without the fundamentals.
Christopher Chouinard of Clemson University discusses with LCGC International how derivatization reshapes steroid mass for sharper liquid chromatography-ion mobility-mass spectrometry (LC-IM-MS) separations.