In-Tube Solid-Phase Microextraction and On-Line Coupling with High-Resolution GC

Here is some of the most popular content posted on LCGC International this week.

Analyzing trace compounds from complex samples often requires purification and pre-concentration, and online coupling of solid-phase extraction (SPE) with liquid chromatography (LC) helps minimize analysis time and solvent/sample use. Monoliths with large macropores are ideal for this coupling due to their low back pressure and versatility in various formats.

Michael Dong recently discussed sample preparation (SP) techniques for small-molecule drug substances and solid dosage forms.

Ion mobility spectrometers can detect trace compounds quickly, though they can face various issues with detecting certain peaks. University of Hannover scientists created a new system for resolving hyper-fast gas chromatography (GC) peaks.

Many multi-column gas chromatography systems use two-position multi-port switching valves, which can suffer from delays in valve switching. Shimadzu researchers aimed to create a new sampling and switching module for these systems.

As the push for green chemistry continues to grow, University of Almeria researchers created a review for ways chromatographic techniques could be more environmentally friendly.