MIP Process Used in Antiepileptic Drug Analysis

Researchers from Universitat Rovira i Virgili (Tarragona, Spain) and the University of Strathclyde (Glasgow, UK) synthesized two molecularly imprinted polymers (MIPs) by precipitation polymerization using the antiepileptic drug carbamazepine as the template molecule and two types of crosslinking agents.

Researchers from Universitat Rovira i Virgili (Tarragona, Spain) and the University of Strathclyde (Glasgow, UK) synthesized two molecularly imprinted polymers (MIPs) by precipitation polymerization using the antiepileptic drug carbamazepine as the template molecule and two types of crosslinking agents. They used liquid chromatography and a solid-phase extraction procedure to compare the molecular recognition character of the polymers. They found that carbamazepine was recognized by both polymers and cross-selectivity for oxcarbazepine, the main metabolite of carbamazepine. They obtained high recoveries of the compounds from spiked human urine.